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Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering
A Farina1, R Labriola1, C Ialongo1
1Department of Experimental Medicine, University of Rome "La Sapienza", 00161, Roma, Lazio, Italy.
Abstract:
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
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