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Related Concept Videos

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The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Techniques to Induce and Quantify Cellular Senescence
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Altered endocytosis in cellular senescence.

Eun-Young Shin1, Nak-Kyun Soung2, Martin Alexander Schwartz3

  • 1Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju, 28644, South Korea.

Ageing Research Reviews
|March 23, 2021
PubMed
Summary

Cellular senescence, a stress response, is increasingly linked to endocytosis pathway changes. Aberrant endocytosis, regulated by specific molecules, can induce senescence, impacting cellular aging and tumor suppression.

Keywords:
AmphiphysinCaveolin-1EndocytosisING1SenescenceβPAK-interacting nucleotide exchange factor (βPIX)

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Induction and Validation of Cellular Senescence in Primary Human Cells
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Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Aging Research

Background:

  • Cellular senescence is a response to various cellular stresses.
  • Endocytic pathways play a crucial role in cellular senescence.
  • Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) are key endocytic processes involved.

Purpose of the Study:

  • To review and discuss molecular regulators of endocytosis-induced senescence.
  • To explore the role of aberrant endocytosis in cellular senescence.
  • To examine how chromatin modifiers and tumor suppressors influence senescence via endocytosis.

Main Methods:

  • Literature review and synthesis of current research on endocytosis and cellular senescence.
  • Analysis of molecular mechanisms linking endocytic pathways to senescence induction.
  • Discussion of the role of specific proteins and pathways in aberrant endocytosis-induced senescence.

Main Results:

  • Alterations in endocytic pathways are significant contributors to cellular senescence.
  • Specific molecular regulators, including chromatin modifiers, can induce senescence through aberrant endocytosis.
  • CME and CavME are implicated as major endocytic routes involved in senescence.

Conclusions:

  • Aberrant endocytosis is a key mechanism in stress-induced cellular senescence.
  • Molecular regulators of endocytosis represent potential targets for modulating senescence.
  • Understanding these pathways is crucial for aging and cancer research.