Related Experiment Video

Updated: Nov 11, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.3K

Altered endocytosis in cellular senescence

Eun-Young Shin1, Nak-Kyun Soung2, Martin Alexander Schwartz3

  • 1Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju, 28644, South Korea.

Ageing Research Reviews
|March 23, 2021
PubMed

Insights

Cellular senescence, a stress response, is increasingly linked to endocytosis pathway changes. Aberrant endocytosis, regulated by specific molecules, can induce senescence, impacting cellular aging and tumor suppression.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Aging Research

Background:

  • Cellular senescence is a response to various cellular stresses.
  • Endocytic pathways play a crucial role in cellular senescence.
  • Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) are key endocytic processes involved.

Purpose of the Study:

  • To review and discuss molecular regulators of endocytosis-induced senescence.
  • To explore the role of aberrant endocytosis in cellular senescence.
  • To examine how chromatin modifiers and tumor suppressors influence senescence via endocytosis.

Main Methods:

  • Literature review and synthesis of current research on endocytosis and cellular senescence.
  • Analysis of molecular mechanisms linking endocytic pathways to senescence induction.
  • Discussion of the role of specific proteins and pathways in aberrant endocytosis-induced senescence.

Main Results:

  • Alterations in endocytic pathways are significant contributors to cellular senescence.
  • Specific molecular regulators, including chromatin modifiers, can induce senescence through aberrant endocytosis.
  • CME and CavME are implicated as major endocytic routes involved in senescence.

Conclusions:

  • Aberrant endocytosis is a key mechanism in stress-induced cellular senescence.
  • Molecular regulators of endocytosis represent potential targets for modulating senescence.
  • Understanding these pathways is crucial for aging and cancer research.
Keywords:
AmphiphysinCaveolin-1EndocytosisING1SenescenceβPAK-interacting nucleotide exchange factor (βPIX)

More Related Videos

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.8K
Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.5K

Related Concept Videos

Maturation of Endosomes01:28

Maturation of Endosomes

The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
5.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.0K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
4.2K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.4K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.5K
Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
3.1K