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Updated: Nov 11, 2025

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Extracellular vesicles in immunomodulation and tumor progression
Carolyn Marar1,2,3, Bartholomew Starich1,4, Denis Wirtz5,6,7,8
1Institute for NanoBiotechnology (INBT), The Johns Hopkins University, Baltimore, MD, USA.
Abstract:
Extracellular vesicles have emerged as prominent regulators of the immune response during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a critical role in immunomodulation. Here, we identify the role of EVs as mediators of communication between cancer and immune cells. This expanded role of EVs may shed light on the mechanisms behind tumor progression and provide translational diagnostic and prognostic tools for immunologists.
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