Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

12.3K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
12.3K
Blood Transfusion01:15

Blood Transfusion

1.3K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
1.3K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

627
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
627
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

114
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
114
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

136
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
136
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

76
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
76

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood loss due to diagnostic testing in extremely preterm infants in 22 European countries: a prospective observational study.

EClinicalMedicine·2026
Same author

Phototherapy, Morbidity, and Mortality in Very Preterm Newborns.

JAMA network open·2026
Same author

Long-Term Risk of Chronic Kidney Disease After Continuous Renal Replacement Therapy in Critically Ill Children: Single-Center PICU Cohort in Sweden, 2008-2021.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Neonatal exchange blood is a rich source of hematopoietic stem and progenitor cells for transplantation.

Haematologica·2026
Same author

Plasma sodium as a predictor of perforation in acute appendicitis: A prospective multi-centre study.

Journal of pediatric surgery·2026
Same author

Optimizing material composition determination in dual-energy computed tomography: a comparative study of a linear model and a fully connected neural network.

Radiation protection dosimetry·2026

Related Experiment Video

Updated: Nov 11, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.9K

[Transfusions in pediatric care - common situations].

Emöke Deschmann1, Andreas Andersson2, Tony Frisk3

  • 1med dr, biträdande överläkare, ME neonatologi, Astrid Lindgrens barnsjukhus; institutionen för kvinnors och barns hälsa, Karolins-ka institutet emoke.deschmann@sll.se.

Lakartidningen
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

Blood transfusions for neonates and children require specific guidelines. Different thresholds for red blood cell transfusions are necessary for preterm neonates and pediatric intensive care patients, with established protocols for massive transfusions.

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K

Related Experiment Videos

Last Updated: Nov 11, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.9K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K

Area of Science:

  • Hematology
  • Pediatrics
  • Neonatology

Background:

  • The hemostatic system in neonates differs significantly from that in children and adults.
  • Hemoglobin levels are critical for tissue oxygenation, especially in rapidly developing neonates.
  • Established clinical guidelines are essential for appropriate transfusion practices.

Purpose of the Study:

  • To outline current transfusion guidelines and considerations for neonatal and pediatric patients.
  • To highlight the unique aspects of neonatal hemostasis and transfusion needs.
  • To emphasize the importance of individualized transfusion decisions based on clinical context.

Main Methods:

  • Review of existing clinical guidelines for blood transfusions in neonates and children.
  • Discussion of specific transfusion thresholds for preterm neonates based on postnatal age and illness severity.
  • Consideration of transfusion practices in pediatric intensive care units and massive transfusion protocols.

Main Results:

  • Healthy neonates possess a balanced hemostatic system.
  • Hemodynamically stable pediatric intensive care patients with hemoglobin >70 g/L generally do not require transfusion.
  • Specific transfusion ratios (20:20:10 mL/kg for RBCs, FFP, platelets) are used for children <50 kg at Karolinska University Hospital.

Conclusions:

  • Transfusions should be administered based on medical indications and individual patient clinical context.
  • Pediatric hospitals should implement massive transfusion protocols.
  • Transfusions in liver disease can potentially increase bleeding risks.