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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Related Experiment Video

Updated: Nov 11, 2025

Identification of Circular RNAs using RNA Sequencing
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Functional long non-coding and circular RNAs in zebrafish.

Gyan Ranjan, Paras Sehgal, Disha Sharma

    Briefings in Functional Genomics
    |March 23, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Zebrafish research reveals new insights into non-coding RNAs like long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). Advanced techniques enable functional analysis and cross-species comparisons for cellular homeostasis studies.

    Keywords:
    circRNAconservationfunctionlncRNAzebrafish

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    Area of Science:

    • * Molecular Biology
    • * Developmental Biology
    • * Genomics

    Background:

    • * Model organisms like zebrafish are crucial for understanding gene and transcript functions in cellular homeostasis.
    • * Advances in deep transcriptomics have led to the identification of numerous novel transcript isoforms, long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs).
    • * Existing databases catalog many identified non-coding RNAs, yet many more await discovery.

    Purpose of the Study:

    • * To explore the utility of zebrafish in delineating molecular mechanisms of novel transcripts and genes.
    • * To highlight the role of transcriptomics in identifying and cataloging lncRNAs and circRNAs.
    • * To showcase how functional analysis and genetic tools in zebrafish can probe the molecular functions of these RNAs.

    Main Methods:

    • * Deep sequencing of transcriptomes in zebrafish to identify lncRNAs and circRNAs.
    • * Functional analysis of specific lncRNA/circRNA candidates (e.g., tie1-AS, ECAL1, CDR1as).
    • * Application of genetic alteration tools such as TALENs and CRISPRs for functional probing.
    • * Integration of experimental and computational techniques for cross-species identification (human and zebrafish).

    Main Results:

    • * Zebrafish serve as a valuable model for studying non-coding RNA functions.
    • * Identification and cataloging of numerous lncRNAs and circRNAs in zebrafish.
    • * Demonstrated utility of specific lncRNAs/circRNAs in providing functional insights.
    • * Enabled functional analysis of lncRNAs/circRNAs using advanced genetic tools.

    Conclusions:

    • * Zebrafish are instrumental in advancing the understanding of non-coding RNA biology.
    • * Novel genetic and transcriptomic tools facilitate the identification and functional characterization of lncRNAs and circRNAs.
    • * Cross-species comparative analysis aids in modeling and understanding RNA functions at the cellular level.