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Chemical scoring by a rapid screening of hazard (RASH) method
T D Jones1, P J Walsh, A P Watson
1Health and Safety Research Division, Oak Ridge National Laboratory, Tennessee 37831-6101.
Abstract:
A rapid screening of hazard method (RASH) is presented for deriving relative potency estimates for hazardous substances. The method utilizes data from any available toxicological database such as the Registry of Toxic Effects of Chemical Substances (RTECS) or EPA's GENE-TOX database on genetic activity profiles. The method has been applied to derive relative potency values and permissible environmental concentrations for 278 chemicals. The derived values have been compared with recommendations of expert committees where possible, and substantial agreement is found.