Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

934
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
934
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

808
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
808
Glaucoma: Overview01:25

Glaucoma: Overview

1.0K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are single-use duodenoscopes a cost-effective alternative to their reusable counterparts? Economic evaluation incorporating environmental impacts.

Gastrointestinal endoscopy·2026
Same author

Low concentration atropine eye drops and progression of myopia in children: multicentre placebo controlled, double masked, randomised trial in the UK (CHAMP-UK).

BMJ (Clinical research ed.)·2026
Same author

Commentary; The ACTIVE trial (Snow et al.). Why did it take so long for ACI to be approved for use in the UK?

Osteoarthritis and cartilage·2026
Same author

PACS plus stratification of acute angle closure glaucoma cases: a retrospective analysis.

Eye (London, England)·2026
Same author

Validating and updating the OHTS-EGPS model predicting 5-year glaucoma risk among patients with ocular hypertension using electronic medical records: a cohort study.

Health technology assessment (Winchester, England)·2026
Same author

A commentary on the updated research priorities in ophthalmology: implications and future directions.

Eye (London, England)·2026

Related Experiment Video

Updated: Nov 11, 2025

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

1.6K

Laser peripheral iridoplasty for chronic angle closure.

James M Bayliss1, Wai Siene Ng2, Norman Waugh3

  • 1Warwick Medical School, University of Warwick, Coventry, UK.

The Cochrane Database of Systematic Reviews
|March 23, 2021
PubMed
Summary

Laser peripheral iridoplasty (LPIp) does not appear to be more effective than other treatments for chronic angle closure. Current evidence suggests LPIp is not clinically superior to laser peripheral iridotomy, medication, or no further treatment.

More Related Videos

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

624
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.6K

Related Experiment Videos

Last Updated: Nov 11, 2025

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

1.6K
Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

624
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.6K

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Interventions

Background:

  • Persistent appositional angle closure occurs in at least one-third of primary angle closure cases post-laser peripheral iridotomy.
  • Laser peripheral iridoplasty (LPIp) is considered for chronic angle closure when initial laser peripheral iridotomy is insufficient.
  • Previous reviews indicated insufficient data on LPIp's clinical effectiveness compared to alternative treatments.

Purpose of the Study:

  • To evaluate the effectiveness of laser peripheral iridoplasty (LPIp) in treating chronic angle closure.
  • To compare LPIp against laser peripheral iridotomy, medical therapy, and no further treatment.
  • To update previous Cochrane Review findings on LPIp efficacy.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) published up to December 20, 2020.
  • Included studies involved suspected, confirmed primary angle closure, or primary chronic angle-closure glaucoma.
  • Four RCTs with 252 participants were analyzed using narrative synthesis due to study heterogeneity.

Main Results:

  • LPIp showed no significant difference in intraocular pressure (IOP), need for further interventions, or medication use compared to laser peripheral iridotomy.
  • Evidence regarding LPIp's effect on anterior segment optical coherence tomography (AS-OCT) measurements was of very low certainty.
  • Limited data on adverse events showed comparable rates between LPIp and control groups; serious events were rare.

Conclusions:

  • Argon LPIp demonstrated no superior clinical effectiveness compared to comparators for chronic angle closure management.
  • Current trial data do not support the routine clinical use of LPIp for chronic angle closure, despite potential anterior chamber benefits.
  • Further research into LPIp is unlikely to be beneficial given the current evidence.