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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Updated: Nov 11, 2025

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
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Rare Breast Cancer Subtypes.

Sarah Jenkins1,2, Megan E Kachur3, Kamil Rechache2

  • 1Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.

Current Oncology Reports
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

This review details rare breast cancer subtypes, outlining their distinct pathological, clinical, and molecular features. Understanding these rare tumors is crucial for guiding treatment decisions despite limited data.

Keywords:
Breast cancerRare breast cancer subtypes

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Breast cancer encompasses common types like invasive ductal and lobular carcinomas, alongside rarer subtypes.
  • These rare breast cancers present unique pathological and clinical characteristics.

Purpose of the Study:

  • To summarize the features of rare breast cancer subtypes.
  • To provide insights into pathological, clinical, and molecular aspects of these rare tumors.

Main Methods:

  • Literature review focusing on rare breast cancer subtypes.
  • Synthesis of existing data on pathological, clinical, and molecular features.

Main Results:

  • Rare breast cancers exhibit distinct features impacting treatment.
  • Molecular characteristics are included where available for each rare tumor type.
  • Limited data exists for optimal treatment approaches in many rare subtypes.

Conclusions:

  • Recognizing the unique features of rare breast cancers is essential for appropriate management.
  • Further research is needed to establish optimal treatment strategies due to data limitations.