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Does insulin resistance trigger thyroid nodule?
Sibel Demiral Sezer1, Elçin Erdoğan Yücel2
1Internal Medicine, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey. drdemiralsibel@yahoo.com.
Internal and Emergency Medicine
|March 23, 2021
Summary
Insulin resistance is linked to thyroid nodules in non-diabetic individuals. Higher insulin resistance values and specific metabolic markers were observed in patients with thyroid nodules, suggesting a significant association.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Thyroidology
Background:
- The connection between insulin resistance and thyroid nodules remains unclear.
- Insulin resistance is a metabolic dysfunction associated with various health conditions.
Purpose of the Study:
- To investigate the association between insulin resistance and thyroid nodules in non-diabetic patients.
- To identify potential metabolic predictors of thyroid nodule development.
Main Methods:
- Retrospective review of 410 internal medicine outpatient records (June 2018 - July 2019).
- Analysis of 216 non-diabetic patients, comparing 105 with thyroid nodules to 110 without.
- Evaluation of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), lipid profiles, and demographic data.
Main Results:
- Patients with thyroid nodules exhibited higher HOMA-IR values, serum triglycerides, total cholesterol, and a greater proportion of women (p < 0.05).
- A significant positive correlation was found between HOMA-IR and the presence of thyroid nodules (r = 0.29, p < 0.05).
Conclusions:
- A significant relationship exists between insulin resistance and thyroid nodule formation in non-diabetic individuals.
- These findings suggest insulin resistance may play a role in thyroid nodule development and warrant further investigation.
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