Evaluation of Myocardial Function Following SADI-S

Area of Science:

• Cardiology
• Bariatric Surgery
• Obesity Medicine

Background:

• Obesity is associated with impaired myocardial function.
• Bariatric surgery aims to induce significant weight loss and improve obesity-related comorbidities.
• Assessing cardiac mechanics is crucial for understanding the impact of weight loss interventions.

Purpose of the Study:

• To evaluate changes in myocardial mechanics, specifically global longitudinal strain (GLS), after single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S).
• To compare left ventricle (LV) and right ventricle (RV) strain before and after SADI-S surgery.

Main Methods:

• Prospective study including 21 obese patients undergoing SADI-S.
• Transthoracic echocardiography performed pre- and post-surgery.
• Two-dimensional speckle-tracking imaging (2DST) used to assess LV and RV strain.

Main Results:

• Significant reduction in Body Mass Index (BMI) post-SADI-S (45.6 to 29.6).
• Significant improvement in LV GLS post-surgery (-19.8% to -22.2%, p < 0.001).
• Significant recovery of RV free-wall strain observed (-19.1% to -21.0%, p = 0.047).

Conclusions:

• SADI-S leads to favorable changes in cardiac deformation parameters.
• Malabsorptive bariatric surgery like SADI-S promotes substantial weight loss.
• Weight loss achieved through SADI-S improves subclinical myocardial function in obese individuals.