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Circ_0061140 promotes metastasis of bladder cancer through adsorbing microRNA-1236

F Feng1, A-P Chen, X-L Wang

  • 1Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

European Review for Medical and Pharmacological Sciences
|March 23, 2021
PubMed

Insights

This study on bladder cancer has been withdrawn due to serious inaccuracies. The article investigated circ_0061140's role in promoting cancer metastasis via microRNA-1236.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer is a significant health concern.
  • Understanding molecular mechanisms driving metastasis is crucial.
  • Circular RNAs (CircRNAs) are emerging as key players in cancer progression.

Purpose of the Study:

  • To investigate the role of circ_0061140 in bladder cancer metastasis.
  • To elucidate the mechanism by which circ_0061140 interacts with microRNA-1236 (miRNA-1236).

Main Methods:

  • The study utilized molecular biology techniques to analyze gene expression and interactions.
  • Functional assays were performed to assess the impact of circ_0061140 on bladder cancer cells.
  • Bioinformatic analysis was employed to predict and validate miRNA targets.

Main Results:

  • The article reported that circ_0061140 promotes bladder cancer metastasis.
  • Findings suggested that circ_0061140 acts as a sponge for miRNA-1236.
  • This interaction was proposed to upregulate oncogenic pathways.

Conclusions:

  • The original study concluded that circ_0061140 is a potential therapeutic target for bladder cancer.
  • However, the article has been withdrawn due to significant errors.
  • The publisher apologizes for any inconvenience caused by the inaccuracies.

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