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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Histone Modification02:32

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Updated: Nov 11, 2025

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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Dysregulated epigenetic modifications in psoriasis.

Chang Zeng1, Lam C Tsoi1,2, Johann E Gudjonsson1,3

  • 1Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

Experimental Dermatology
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

Psoriasis incidence is rising, with epigenetic changes like DNA methylation and non-coding RNA expression implicated in its development. Targeting these epigenetic mechanisms offers a promising new treatment strategy for psoriasis.

Keywords:
DNA methylationepigeneticshistone modificationnon-coding RNApsoriasis

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Area of Science:

  • Dermatology
  • Epigenetics
  • Molecular Biology

Background:

  • Psoriasis incidence is increasing, yet its pathogenic factors remain unclear.
  • Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA expression, are increasingly recognized in psoriasis pathogenesis.
  • Aberrant epigenetic patterns are observed in psoriatic skin lesions.

Purpose of the Study:

  • To summarize evidence linking epigenetic dysregulation to psoriasis susceptibility and pathogenesis.
  • To identify factors responsible for epigenetic modifications in psoriasis.
  • To provide directions for future clinical applications of epigenetic therapy in psoriasis.

Main Methods:

  • Literature review of recent studies on epigenetics and psoriasis.
  • Analysis of evidence for specific epigenetic alterations (DNA methylation, histone modifications, non-coding RNAs).
  • Examination of factors influencing epigenetic modifications in psoriasis.

Main Results:

  • Epigenetic dysregulation, including altered DNA methylation, histone modifications, and non-coding RNA expression, is a significant factor in psoriasis pathogenesis.
  • Reversing these epigenetic changes has demonstrated improvements in psoriatic phenotypes.
  • Various factors contribute to the epigenetic modifications observed in psoriatic skin.

Conclusions:

  • Epigenetic mechanisms play a crucial role in psoriasis development and progression.
  • Epigenetic therapy represents a potential and promising therapeutic strategy for managing psoriasis.
  • Further research into epigenetic factors and their modulation is warranted for clinical translation.