Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarkers of angiogenesis in Alzheimer's disease: Systematic review and meta-analysis.

Journal of Alzheimer's disease : JAD·2026
Same author

A Physiological Microfluidic Blood-Brain-Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation.

Advanced healthcare materials·2026
Same author

ImmuniT Platform for Improved Neoantigen Prediction in Lung Cancer.

Vaccines·2025
Same author

Development of a novel single channel arteriole microphysiological system for characterizing leukocyte-endothelial interactions.

Journal of clinical and translational science·2025
Same author

A physiological microfluidic blood-brain-barrier model for in vitro study of nanoparticle trafficking and accumulation.

bioRxiv : the preprint server for biology·2025
Same author

CDC42-effector interaction inhibitors alter patterns of vessel arborization in skin and tumors <i>in vivo</i>.

iScience·2025
Same journal

Physics-Informed Machine Learning in Biomedical Science and Engineering.

Annual review of biomedical engineering·2026
Same journal

Advancements and Challenges in Computer-Assisted Medical Interventions for Image-Guided Prostate Cancer Treatments.

Annual review of biomedical engineering·2026
Same journal

Recent Advances in mRNA Therapeutic Cancer Vaccines.

Annual review of biomedical engineering·2026
Same journal

Artificial Intelligence-Based Analysis of Laparoscopic Imaging for Intraoperative Surgical Decision Support.

Annual review of biomedical engineering·2026
Same journal

Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.

Annual review of biomedical engineering·2026
Same journal

Digital Twins for Biofluids.

Annual review of biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.4K

Engineering Vascularized Organoid-on-a-Chip Models.

Venktesh S Shirure1, Christopher C W Hughes2, Steven C George1

  • 1Department of Biomedical Engineering, University of California, Davis, California 95616, USA;

Annual Review of Biomedical Engineering
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

Researchers are advancing 3D organoid technology by integrating microfluidics and stem cells to create vascularized organoids for studying organ function and disease. Future systems aim to couple multiple vascularized organs for dynamic physiological responses.

Keywords:
angiogenesismicrophysiological systemsorgan-on-a-chipself-assembled vasculaturetumor-on-a-chipvasculogenesis

More Related Videos

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

321
In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.1K

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.4K
Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
06:12

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

321
In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

3.1K

Area of Science:

  • * Advanced regenerative medicine and tissue engineering.
  • * Stem cell biology and microfluidic technology integration.
  • * Development of complex 3D organoid models.

Background:

  • * Vascularization is crucial for organ function and inter-organ communication.
  • * Current in vitro models lack integrated vascular networks.
  • * Organoids offer a platform to study organ-specific functions and disease progression.

Purpose of the Study:

  • * To review strategies for creating vascularized organoids.
  • * To survey existing applications of vascularized organoids in organ function and tumor modeling.
  • * To propose future directions for multi-organoid systems.

Main Methods:

  • * Discussion of general strategies for vascularizing organoids.
  • * Analysis of common source materials for organoid development.
  • * Survey of published research on vascularized organoid applications.

Main Results:

  • * Established methods for creating vascularized organoids are presented.
  • * Examples of organoid applications in simulating organ function and tumor growth are highlighted.
  • * The importance of vascular networks for organoid integration is emphasized.

Conclusions:

  • * Vascularized organoids are essential for recreating organ-level function in vitro.
  • * Future research should focus on developing multi-organoid systems with dynamic vascular networks.
  • * This technology holds promise for personalized medicine and disease modeling.