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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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In-vitro Mutagenesis01:16

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Updated: Nov 11, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Human gene therapy: A scientometric analysis.

Wuyuan Zhou1, Xiang Wang2

  • 1Zhejiang Academy of Science and Technology Information, Hangzhou 310006, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

Gene therapy research shows recovery post-2013 but lacks momentum. Future success hinges on advanced technologies like CRISPR-Cas and CAR-T cell therapies for effective gene delivery.

Keywords:
Gene therapyLife cycleResearch hotspotsSciValVisualization

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Area of Science:

  • Biotechnology and Biomedical Sciences
  • Genetics and Genomics
  • Medical Research

Background:

  • Gene therapy has undergone significant development, with a notable recovery in research activity observed after 2013.
  • Despite recovery, key performance indicators such as scholarly output growth and citation impact remain suboptimal, suggesting a need for renewed research momentum.

Purpose of the Study:

  • To map the landscape, identify trends, and delineate research frontiers in gene therapy.
  • To analyze the knowledge structure and research hotspots within the gene therapy field.
  • To inform scientific planning and decision-making through evidence-based bibliometric analysis.

Main Methods:

  • Systematic retrieval of 62,961 peer-reviewed studies (1996-2020) from Scopus and Web of Science.
  • Analysis of 42,120 Inpadoc patent families from Derwent Innovation.
  • Application of bibliometric approaches, citation analysis, co-citation analysis, and co-word analysis with Natural Language Processing (NLP).

Main Results:

  • Gene therapy research experienced a decline followed by a recovery starting in 2013.
  • Current metrics indicate a lack of research momentum, with weak growth in authors, output, citations, and high-impact publications.
  • Knowledge structure analysis revealed key research hotspots and trends in gene therapy.

Conclusions:

  • The future trajectory of gene therapy is contingent upon advancements in cutting-edge technologies, including CRISPR-Cas systems, CAR-T cell therapies, and novel gene delivery vectors.
  • Bibliometric analysis provides a robust framework for dissecting the field and guiding strategic planning in gene therapy research.
  • Further innovation in gene delivery and therapeutic platforms is crucial for sustained progress and clinical translation.