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Updated: Nov 11, 2025
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
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The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders
Soudeh Ghafouri-Fard1, Afete Abak2, Faranak Fattahi3
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Summary
Nuclear factor-kappa B (NF-κB) interacts with non-coding RNAs like miRNAs and lncRNAs to regulate gene expression. This complex network is crucial in neoplastic and non-neoplastic disorders.
Area of Science:
- Molecular Biology
- Genetics
- Immunology
Background:
- Nuclear factor-kappa B (NF-κB) is a key transcription factor regulating immune responses and gene expression.
- NF-κB interacts with non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), forming complex regulatory networks.
- These interactions are implicated in the pathophysiology of various human diseases, encompassing both neoplastic and non-neoplastic conditions.
Purpose of the Study:
- To review the intricate functions of NF-κB-related miRNAs and lncRNAs.
- To explore their roles in the development and progression of neoplastic and non-neoplastic human disorders.
Main Methods:
- Literature review focusing on studies investigating NF-κB interactions with miRNAs and lncRNAs.
- Analysis of functional relationships and regulatory mechanisms.
- Examination of roles in cancer and inflammatory conditions.
Main Results:
- NF-κB forms complex regulatory networks with miRNAs and lncRNAs, influencing gene expression.
- Specific lncRNAs like MALAT1 and NKILA, and miRNAs such as miR-146a/b, have demonstrated functional interactions with NF-κB.
- The regulatory role of miRNAs on NF-κB is more extensively characterized than that of lncRNAs.
Conclusions:
- NF-κB-associated non-coding RNAs are critical players in human diseases.
- Understanding these interactions offers potential therapeutic targets for neoplastic and non-neoplastic conditions.
- Further research into lncRNA-NF-κB interactions is warranted.
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