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Behçet's Disease Is Associated with Multiple Sclerosis and Rheumatoid Arthritis: A Korean Population-Based Study
Jin Hyung Jung1, Kyung Do Han2, Young Bok Lee3
1Department of Biomedicine and Health Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea.
Background:
No epidemiologic study has previously reported on the associations among Behçet's disease (BD) and autoimmune disorders.
Objectives:
To investigate the association between BD and the autoimmune disorders multiple sclerosis and rheumatoid arthritis.
Methods:
Medical records of patients newly diagnosed with BD (n = 6,214) in 2012-2017 were analyzed using data entered into a large, nationwide database from 2007 to 2017. An age- and sex-matched control population of individuals without BD was sampled at a ratio of controls:BD cases of 3:1 (n = 18,642). Both cohorts were analyzed for the presence of multiple sclerosis or rheumatoid arthritis within a minimum of 5 years prior to their BD diagnosis.
Results:
Patients with BD had significantly higher odds ratios (ORs) for multiple sclerosis (8.85 [95% CI 2.36-33.17]) and rheumatoid arthritis (4.62 [95% CI 3.35-6.35]) than the control group after adjustment for diabetes mellitus, hypertension, and dyslipidemia. BD patients aged <40 years had a higher proportion of rheumatoid arthritis (OR 23.91, 95% CI 5.50-103.9) than older patients (OR 3.96, 95% CI 2.83-5.54).
Conclusion:
Our results suggest that BD is associated with multiple sclerosis and rheumatoid arthritis.
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