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Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement.

Daniel Ontaneda1, Praneeta C Raza1, Kedar R Mahajan1

  • 1Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland, OH 44195, USA.

Brain : a Journal of Neurology
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PubMed
Summary
This summary is machine-generated.

Deep grey matter injury is crucial in multiple sclerosis (MS), impacting disability. Consensus was reached on advanced MRI techniques for studying MS deep grey matter pathology and clinical relevance.

Keywords:
MRIatrophydeep grey mattermultiple sclerosisthalamus

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Area of Science:

  • Neurology
  • Neuroimaging
  • Pathology

Background:

  • Multiple sclerosis (MS) traditionally viewed as white matter disease.
  • Emerging evidence highlights significant deep grey matter (DGM) injury in MS.
  • DGM pathology is linked to clinical and cognitive disability in MS patients.

Framework:

  • The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative convened a workshop.
  • Consensus was established on key imaging topics concerning DGM in MS.
  • Focus on magnetic resonance (MR) techniques for DGM assessment.

Implementation:

  • Review of current knowledge on DGM injury in MS from an imaging standpoint.
  • Inclusion of histopathology insights and MR image acquisition/processing for DGM.
  • Discussion of clinical relevance and specific DGM regions of interest.

Implications:

  • Thalamic volume and other DGM MRI metrics show potential as clinical trial endpoints.
  • Highlights the need for standardized methods in DGM imaging for MS research.
  • Proposes future research directions to refine DGM analysis and interpretation in MS.