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Transcranial Alternating Current Stimulation Reduces Network Hypersynchrony and Persistent Vertigo.

Sangtae Ahn1,2,3,4, Diamond Gleghorn5, Benjamin Doudican6

  • 1School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, South Korea.

Neuromodulation : Journal of the International Neuromodulation Society
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

Mal de Débarquement Syndrome (MdDS) is linked to brain hypersynchrony. Transcranial alternating current stimulation (tACS) effectively reduced this hypersynchrony and vertigo symptoms in MdDS patients.

Keywords:
Auditory steady-state responseMal de Débarquement Syndromepersistent oscillating vertigotranscranial alternating current stimulation

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Area of Science:

  • Neuroscience
  • Neurology
  • Biomedical Engineering

Background:

  • Mal de Débarquement Syndrome (MdDS) is characterized by persistent vertigo after motion exposure.
  • MdDS is associated with reduced functional connectivity in fronto-parieto-occipital regions.
  • Auditory steady-state response (ASSR) may indicate hypersynchrony in MdDS.

Purpose of the Study:

  • To investigate the association between MdDS vertigo and hypersynchrony measured by ASSR.
  • To compare ASSR in MdDS patients and healthy controls.
  • To assess the effect of transcranial alternating current stimulation (tACS) on ASSR in MdDS patients.

Main Methods:

  • Treatment-refractory MdDS patients received fronto-parieto-occipital tACS (alpha-in-phase, alpha-antiphase, gamma-antiphase control).
  • The most effective protocol was administered over 10-12 sessions (20-min each, 2-4 mA).
  • ASSR was measured before and after tACS treatment.

Main Results:

  • MdDS patients exhibited elevated ASSR compared to controls at baseline.
  • Responders to tACS showed a significant decrease in 40 Hz-ASSR compared to non-responders.
  • Antiphase alpha-tACS significantly reduced 40 Hz-ASSR and improved symptoms.

Conclusions:

  • tACS can reduce network-level hypersynchrony and sensory entrainment susceptibility in MdDS.
  • This study demonstrates noninvasive brain stimulation for reducing vertigo in MdDS.
  • This approach may benefit other conditions involving pathological neural network coupling.