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Predictive value of coagulation tests in arterial thrombosis
1Istituto di Medicina Interna, Università degli Studi ed Ospedale Maggiore, Milano.
La Ricerca in Clinica E in Laboratorio
|January 1, 1988
Summary
High fibrinogen and factor VII levels predict arterial thrombotic diseases in healthy individuals. These clotting factors are more predictive than cholesterol for arterial occlusive diseases.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Epidemiology
Background:
- Arterial thrombotic diseases pose a significant health burden.
- Established risk factors include plasma cholesterol.
- The role of hemostatic parameters requires further elucidation.
Purpose of the Study:
- To evaluate the predictive value of hemostatic parameters for arterial thrombotic diseases.
- To assess the association between fibrinogen, factor VII, and arterial occlusive diseases.
- To compare the predictive power of clotting factors with traditional risk factors.
Main Methods:
- Analysis of data from five large-scale prospective studies.
- Estimation of predictive values of hemostatic parameters in healthy individuals.
- Statistical association analysis between clotting factors and disease incidence.
Main Results:
- Consistent statistically significant association found between hyperfibrinogenemia and arterial thrombotic diseases.
- Increased levels of factor VII associated with higher incidence of ischemic heart disease in two studies.
- Fibrinogen and factor VII showed a stronger relationship with arterial occlusive diseases than plasma cholesterol.
Conclusions:
- Alterations in the clotting system play a crucial pathogenetic role in occlusive arterial diseases.
- Hyperfibrinogenemia and elevated factor VII are significant predictors of arterial thrombotic events.
- Hemostatic parameters offer valuable insights into arterial disease risk assessment.