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Lurasidone for Adolescents With Complex Mental Disorders: A Case Series
Tom B Mole1, Yulia Furlong2, Richard J Clarke2
1Ramsay Health Care, Perth, Western Australia, Australia.
Journal of Pharmacy Practice
|March 24, 2021
Summary
This study explored lurasidone
Area of Science:
- Psychiatry and Behavioral Sciences
- Pharmacology and Therapeutics
Background:
- Limited data exists on atypical antipsychotic lurasidone in adolescent populations.
- Real-world clinical settings require understanding of lurasidone's efficacy in complex cases.
- Adolescents with treatment-resistant conditions need effective therapeutic options.
Purpose of the Study:
- To evaluate the effects and tolerability of lurasidone in adolescents with complex mental health conditions.
- To assess lurasidone's utility in real-life clinical practice for treatment-resistant cases.
- To explore lurasidone's safety and potential benefits in a non-trial adolescent cohort.
Main Methods:
- Retrospective case-note audit of 6 adolescents (aged 14-17) treated with lurasidone.
- Inclusion criteria: adolescents with complex comorbidities unresponsive to other therapies.
- Data collection focused on clinical response, tolerability, and adverse effects.
Main Results:
- Clinically positive response to lurasidone observed in 3 out of 6 adolescents.
- Equivocal/marginal response in 2 cases; ineffective in 1 case.
- No reported cases of poor tolerance or adverse effects; positive impact on mood symptoms noted.
Conclusions:
- Lurasidone shows potential for adolescents with complex needs, particularly for mood symptom improvement.
- Preliminary findings suggest a favorable risk-benefit profile and weight-sparing effect.
- Further research is warranted for lurasidone's use in the adolescent population.
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