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Related Concept Videos

Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Genotype-expression interactions for BDNF across human brain regions.

Patrick Devlin1, Xueyuan Cao2, Ansley Grimes Stanfill2

  • 1Department of Anatomy and Neurobiology, College of Graduate Health Sciences, University of Tennessee Health Science Center, 920 Madison Ave. #807, Memphis, TN, 38163, USA. Pdevlin2@uthsc.edu.

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|March 24, 2021
PubMed
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Genetic variations in brain-derived neurotrophic factor (BDNF) impact gene expression in key brain regions. These findings link BDNF SNPs to psychiatric disorders, suggesting new diagnostic and therapeutic targets.

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BDNFBrainCognitive disordersGenetic expressionHuman subjects

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Genetic variations in brain-derived neurotrophic factor (BDNF) are linked to psychiatric disorders like depression and schizophrenia.
  • Altered BDNF gene expression is a potential mechanism for these disorders.
  • Genotype-expression interactions in relevant brain regions remain understudied.

Purpose of the Study:

  • To investigate genotype-expression interactions for BDNF across multiple brain regions.
  • To identify specific single nucleotide polymorphisms (SNPs) associated with BDNF expression.
  • To explore the relevance of these findings for psychiatric disorders.

Main Methods:

  • Analysis of BDNF gene expression and single nucleotide polymorphisms (SNPs) in human brain samples.
  • Utilized false discovery rate (FDR) to identify significant associations.
  • Haplotype block analysis to group associated SNPs.

Main Results:

  • Identified significant associations between 61 SNPs and BDNF expression in the cerebellum, 55 in the cortex, and others in the nucleus accumbens, caudate, and cerebellar hemisphere.
  • Discovered 30 SNPs within two haplotype blocks associated with BDNF expression changes across all five studied brain regions.
  • These haplotype blocks contain SNPs previously linked to panic disorder, addiction, bipolar disorder, OCD, major depressive disorder, and epilepsy.

Conclusions:

  • This study supports the association of BDNF variants with expression changes in critical brain regions.
  • These expression changes may contribute to behavioral phenotypes observed in disorders of compulsion, impulsivity, and addiction.
  • Identified SNPs warrant further investigation as potential therapeutic and diagnostic targets for psychiatric disorders.