Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

2,2,2-Trifluoroethanol toxicity in aged rats.

J C Kim1, L S Kaminsky

  • 1Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.

Toxicologic Pathology
|January 1, 1988
PubMed
Summary

Toxic anesthetic metabolite 2,2,2-trifluoroethanol (TFE) causes significant organ damage in aged rats. Studies reveal TFE induces severe liver, kidney, and brain lesions, accelerating aging indicators.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

Lymph node mapping-based optimal bowel-resection margin and central radicality in colon cancer surgery: an international, prospective, observational cohort study.

ESMO gastrointestinal oncology·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Erratum.

Veterinarni medicina·2025
Same author

Sensitive skin is associated with contact sensitization and decreased nociceptive threshold.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

Physical review letters·2022

Area of Science:

  • Toxicology
  • Gerontology
  • Pharmacology

Background:

  • Anesthetics can metabolize into toxic compounds like 2,2,2-trifluoroethanol (TFE).
  • Cytochrome P-450 enzymes catalyze TFE toxicity.
  • Hepatic mixed function oxidase systems show age-related differences.

Purpose of the Study:

  • To investigate the toxicity of TFE in aged Wistar rats.
  • To evaluate pathological changes induced by chronic sublethal TFE exposure.

Main Methods:

  • Aged Wistar rats (36 months old) received weekly sublethal doses of TFE (0.10 g/kg) for 5 weeks.
  • Pathological and ultrastructural examinations of liver and other organs were performed.
  • Cytochrome P-450 concentrations were measured.

Main Results:

  • TFE induced severe hepatocyte degeneration, bile duct hyperplasia, lipofuscin accumulation, and preneoplastic nodules.
  • Gastric, intestinal, testicular, and kidney damage (glomerulonephropathy) were observed.
  • Enhanced aging signs, including white matter vacuolation in the brain, were noted.

Conclusions:

  • TFE causes significant multi-organ toxicity and exacerbates aging processes in aged rats.
  • The study highlights the risks associated with anesthetic metabolites in elderly populations.
  • Further research into age-dependent TFE metabolism and toxicity is warranted.

Related Experiment Videos