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Large-Scale and Multiscale Networks in the Rodent Brain during Novelty Exploration.

Michael X Cohen1, Bernhard Englitz2, Arthur S C França3

  • 1Donders Centre for Medical Neuroscience, Radboud University Medical Center, 6525 GA, Nijmegen mikexcohen@gmail.com.

Eneuro
|March 24, 2021
PubMed
Summary

Researchers mapped brain activity across multiple scales in mice, revealing reproducible, individual-specific neural networks during exploration. These findings highlight the complex coordination of brain regions and frequencies.

Keywords:
cortexeigendecompositionlocal field potentialnetworksoscillationssource separation

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Neural activity coordination across scales is crucial for cognition but challenging to study.
  • Limited data and complex analysis hinder cross-scale neural investigations.

Purpose of the Study:

  • To characterize large-scale neural networks across multiple spatial, spectral, and temporal scales.
  • To investigate inter-regional coordination during naturalistic behavior in mice.

Main Methods:

  • Applied frequency-resolved multivariate source-separation analyses.
  • Analyzed simultaneous spiking and local field potential (LFP) data from prefrontal cortex, parietal cortex, and hippocampus in freely-moving mice.
  • Investigated neural activity across a wide frequency range (2-200 Hz).

Main Results:

  • Identified multidimensional, inter-regional networks reproducible within animals but variable across individuals.
  • Observed prominent theta band (4-10 Hz) networks with equal regional contribution and strong synchronization.
  • Characterized a complex landscape of large-scale functional activations during open-field exploration.

Conclusions:

  • Demonstrated a multidimensional framework for understanding large-scale brain network dynamics.
  • Highlighted individual variability in neural network architecture.
  • Provided insights into the spectral and spatial coordination of neural activity during behavior.