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Lactate-supported synaptic function in the rat hippocampal slice preparation.

A Schurr1, C A West, B M Rigor

  • 1Department of Anesthesiology, University of Louisville School of Medicine, KY 40292.

Science (New York, N.Y.)
|June 3, 1988
PubMed
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Lactate can fuel brain energy metabolism, supporting normal synaptic function in rat hippocampal slices. This finding suggests lactate may serve as a crucial alternative energy source during cerebral ischemia.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Cellular Metabolism

Background:

  • Cerebral energy metabolism primarily relies on glucose.
  • The role of lactate as a direct energy substrate for the brain is debated.
  • Conditions like cerebral ischemia lead to lactate accumulation.

Purpose of the Study:

  • To investigate if lactate can serve as a sole energy substrate for cerebral energy metabolism.
  • To determine the metabolic pathway utilized by lactate in neuronal tissue.
  • To assess the potential of lactate as an alternative fuel source during impaired glucose supply.

Main Methods:

  • Utilized rat hippocampal slices.
  • Assessed synaptic function with and without glucose or lactate as the sole energy source.

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  • Employed the glycolytic inhibitor iodoacetic acid to differentiate metabolic pathways.

    • Main Results:

    • Lactate alone sustained normal synaptic function in hippocampal slices for extended periods.
    • Lactate reactivated glucose-depleted slices, restoring synaptic activity.
    • Lactate-supported function remained intact when glycolysis was inhibited, unlike glucose-supported function.

    Conclusions:

    • Lactate can be directly metabolized via pyruvate to fuel the tricarboxylic acid cycle for cerebral energy.
    • Lactate represents a viable alternative energy substrate for the brain.
    • Lactate may play a significant role in maintaining brain function during ischemic events.