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Long non-coding RNA RP11-379k17.4 derived microRNA-200c-3p modulates human endometrial cancer by targeting Noxa

Weijuan Xin1, Xiaodong Gao2, Peng Zhao3

  • 1Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen-Yang Road, Shanghai 200090, China.

Journal of Cancer
|March 24, 2021
PubMed

Insights

This study identifies a novel long noncoding RNA (lncRNA) network involved in endometrial cancer (EC). This lncRNA-based ceRNA network plays a significant role in EC

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Endometrial cancer (EC) is a significant gynecological malignancy.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer.
  • Endogenous competitive RNA (ceRNA) networks regulate gene expression post-transcriptionally.

Purpose of the Study:

  • To investigate the function of lncRNA-related ceRNA networks in endometrial cancer.
  • To identify specific lncRNAs interacting with microRNA-200c-3p in EC.
  • To elucidate the role of the microRNA-200c-3p-noxa network in EC pathogenesis.

Main Methods:

  • Analysis of 45 endometrial cancer tissues and 45 normal endometrium samples.
  • Utilized StarbaseV2.0 to predict lncRNAs interacting with microRNA-200c-3p.
  • Selected lncRNAs based on polyadenylation characteristics and differential expression in EC versus normal tissue.

Main Results:

  • Identified Rp11-379k17.4, a novel noncoding RNA, as a key component of the EC ceRNA network.
  • Rp11-379k17.4 demonstrated effective ceRNA activity within the microRNA-200c-3p-noxa network.
  • The study highlights the dysregulation of specific lncRNAs in endometrial cancer.

Conclusions:

  • LncRNAs with microRNA response elements (MREs) are crucial in EC post-transcriptional regulation.
  • The identified lncRNA-ceRNA network, particularly involving Rp11-379k17.4, offers potential therapeutic targets for EC.
  • Further research into lncRNA functions can advance understanding and treatment of endometrial cancer.
Keywords:
ceRNAslncRNA RP11-379k17.4, endometrial cancer, microRNA-200c-3p, noxa

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