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Related Experiment Video

Updated: Nov 11, 2025

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Advances in Chronic Obstructive Pulmonary Disease Imaging.

Wojciech R Dolliver¹, Alejandro A Diaz¹

¹Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Barcelona Respiratory Network Reviews

|March 24, 2021

Summary

Computed tomography (CT) imaging reveals lung structure changes in chronic obstructive pulmonary disease (COPD). Early CT findings like emphysema and airway loss predict faster lung function decline and mortality risk.

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Published on: January 22, 2013

Area of Science:

Pulmonary Medicine
Radiology
Medical Imaging

Background:

Chest computed tomography (CT) provides crucial in vivo insights into lung structure.
CT imaging aids in understanding chronic obstructive pulmonary disease (COPD), detecting early changes, and quantifying structures.

Purpose of the Study:

To review recent advancements in CT imaging for COPD.
To highlight the role of CT in understanding COPD subtypes, progression, and extra-pulmonary manifestations.

Main Methods:

Review of novel CT imaging techniques and longitudinal data in COPD research.
Analysis of CT-derived abnormalities such as emphysema and small airway disease.
Assessment of extra-pulmonary findings like right ventricle enlargement and low muscle mass.

Main Results:

CT abnormalities are present even in smokers without COPD and those with mild-to-moderate disease.
Significant airway loss correlates with the highest decline in lung function in mild-to-moderate COPD.
Extra-pulmonary manifestations on CT are linked to increased all-cause mortality risk.

Conclusions:

CT imaging is vital for early COPD detection, subtype characterization, and prognosis.
Lung structure abnormalities identified by CT, including emphysema and small airway disease, predict disease progression.
Extra-pulmonary findings on CT offer prognostic information beyond lung function.