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Updated: Nov 11, 2025
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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
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The COVIDome Explorer Researcher Portal
Kelly D Sullivan1,2, Matthew D Galbraith1,3, Kohl T Kinning1
1Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Medrxiv : the Preprint Server for Health Sciences
|March 24, 2021
Summary
This study presents the COVIDome, a comprehensive multi-omics dataset from hospitalized COVID-19 patients. The COVIDome Explorer enables real-time data analysis, revealing key molecular signatures linked to C-reactive protein (CRP) levels and disease severity.
Area of Science:
- Immunology
- Genomics
- Metabolomics
Background:
- COVID-19 pathology involves complex molecular and cellular dysregulation.
- Integrated multi-omics data is crucial for understanding COVID-19 pathogenesis.
- Existing datasets lack comprehensive, real-time analysis capabilities.
Approach:
- Generated the COVIDome, a multidimensional dataset from hospitalized COVID-19 patients.
- Included whole blood transcriptome, plasma proteomics, cytokine profiling, metabolomics, and immune cell phenotyping.
- Developed the COVIDome Explorer, an online portal for real-time data analysis and visualization.
Key Points:
- Multi-omics analysis identified biosignatures associated with C-reactive protein (CRP).
- CRP levels correlated with damage-associated molecular patterns and serpin depletion.
- Mitochondrial metabolism dysregulation was observed in relation to CRP levels.
Conclusions:
- The COVIDome provides a valuable resource for COVID-19 research.
- The COVIDome Explorer facilitates rapid data sharing and hypothesis testing.
- This integrated approach accelerates discoveries in COVID-19 pathogenesis and prognosis.
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