Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

676
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
676
Masking and Demasking Agents01:19

Masking and Demasking Agents

3.1K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.1K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.0K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.0K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

758
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
758

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine-Learned Extrapolation of Quantum Mechanical Energies in Implicit Solvent from Short to Long Oligopeptides.

Journal of chemical information and modeling·2026
Same author

Single stereocenter inversion of a cyclic tetrapeptide enables the detoxification of lead-exposed mice.

Chemical science·2026
Same author

Generating Molecular Diversity via Addition of Nucleophiles to Electron-Deficient [3]Dendralenes: An Exploratory Study.

The Journal of organic chemistry·2026
Same author

Can Silver(I) Act as a Hydrogen-Bond Acceptor? Spectroscopic and Computational Exploration of the Ag···H<sup>+</sup> Bonds in the Gas Phase and in Solvent.

Inorganic chemistry·2025
Same author

Chemical richness and diversity of uncultivated 'Entotheonella' symbionts in marine sponges.

Nature chemical biology·2025
Same author

Synthesis of <i>m</i>,<i>n</i>‑Diaza[<i>n</i>]helicenes via Skeletal Editing of Indeno[2,1‑<i>c</i>]fluorene-5,8-diols.

JACS Au·2025
Same journal

A Domino-Synthesized Dicoordinate Copper(I) Bis-imidazopyridine Complex Triggering Cuproptosis/Ferroptosis for Enhanced Cancer Immunotherapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Mirror-Symmetric Organic Two-Dimensional Crystals for Alternative Photon Transport Pathways.

Angewandte Chemie (International ed. in English)·2026
Same journal

Cobalt-Catalyzed Migratory E-Selective Asymmetric Aza-Nozaki-Hiyama-Kishi Coupling.

Angewandte Chemie (International ed. in English)·2026
Same journal

Facile Synthesis of α,ω-Dihydroxy Telechelic Macromonomers From Ethylene and α-Olefins for Recyclable Alternating Block Copolymers.

Angewandte Chemie (International ed. in English)·2026
Same journal

Multi-Atom Sub-Nanometer Assemblies on Interpenetrating Multi-Chambered N/C Nanospheres.

Angewandte Chemie (International ed. in English)·2026
Same journal

A Synergistic C<sub>2+</sub> Alcohols/Olefins-Intermediated Pathway Boosts CO<sub>2</sub> Hydrogenation to Aromatics.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Nov 11, 2025

A Study of the Complexation of MercuryII with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry
12:59

A Study of the Complexation of MercuryII with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry

Published on: January 8, 2016

8.2K

Potent Cyclic Tetrapeptide for Lead Detoxification.

Tagwa A Mohammed1, Christoph M Meier1, Tadeáš Kalvoda2

  • 1Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Angewandte Chemie (International Ed. in English)
|March 24, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a cyclic tetrapeptide that selectively binds lead (Pb) and removes its toxic effects at the cellular level. This novel peptide shows superior potency and lower toxicity compared to current treatments for lead poisoning.

Keywords:
chelation therapylead poisoningmetal selectivitypeptidesrational design

More Related Videos

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.1K
Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
10:30

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT

Published on: September 2, 2015

10.5K

Related Experiment Videos

Last Updated: Nov 11, 2025

A Study of the Complexation of MercuryII with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry
12:59

A Study of the Complexation of MercuryII with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry

Published on: January 8, 2016

8.2K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.1K
Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
10:30

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT

Published on: September 2, 2015

10.5K

Area of Science:

  • Environmental Science
  • Toxicology
  • Medicinal Chemistry

Background:

  • Lead (Pb) poisoning is a significant global health concern affecting large populations.
  • Current medications for lead poisoning have limitations, including toxicity and poor metal selectivity.
  • There is a critical need for effective and safe treatments for lead poisoning.

Purpose of the Study:

  • To develop a novel therapeutic agent for lead poisoning with improved efficacy and safety.
  • To investigate the selective binding of a cyclic tetrapeptide to lead (Pb).
  • To evaluate the therapeutic potential of this peptide in eradicating lead's toxic effects.

Main Methods:

  • Design and synthesis of a cyclic tetrapeptide.
  • Experimental characterization of the lead-peptide complex.
  • Computational analysis of the lead-peptide interaction.
  • In vitro assessment of the peptide's efficacy and toxicity.

Main Results:

  • A cyclic tetrapeptide was identified that selectively binds lead (Pb) with high affinity.
  • The lead-peptide complex demonstrated remarkable strength and stability.
  • The peptide effectively eradicated lead's toxic effects at the cellular level.
  • The developed peptide exhibited superior potency compared to existing state-of-the-art drugs and showed no significant toxicity.

Conclusions:

  • The cyclic tetrapeptide represents a promising new therapeutic candidate for lead poisoning.
  • Its high selectivity, potency, stability, and lack of toxicity offer significant advantages over current treatments.
  • This peptide has the potential to be a valuable remedy for mitigating the health impacts of lead exposure.