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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
First report of bla GES-1 in Proteus mirabilis clinical isolates
Elizabeth Maria Bispo Beltrão1, Érica Maria de Oliveira1, Ana Catarina de Souza Lopes1
1Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Recife, PE, Brasil.
Abstract:
Proteus mirabilis is one of the main pathogens causing urinary tract infections and sepsis. To our knowledge, this is the first report of a P. mirabilis hosting bla GES. The presence of these genes was determined using PCR and sequencing. We identified the presence of bla GES-1 in all three isolates. In addition, we identified the bla KPC-2 and bla NDM-1 genes in the two strains. These data emphasize the importance of monitoring and surveillance of all enterobacteria. The circulation of P. mirabilis strains carrying bla GES-1 constitutes a new scenario of resistance in this species and should be an epidemiological alert for global health.
Insights
This study reports Proteus mirabilis strains carrying bla GES genes, a novel finding for this pathogen. This discovery highlights the urgent need for surveillance of antibiotic resistance in enterobacteria.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Proteus mirabilis is a significant cause of urinary tract infections and sepsis.
- The emergence of antibiotic resistance in bacterial pathogens poses a global health threat.
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