Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

1.5K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.5K
Necrosis01:16

Necrosis

5.3K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
5.3K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

249
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
249
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.0K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

The British journal of dermatology·2021
Same author

The global incidence of bullous pemphigoid: a systematic review and meta-analysis.

The British journal of dermatology·2021
Same author

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

BMC medical research methodology·2021
Same author

What is the demand for out-of-hours dermatology? A UK-based region-wide survey of dermatology demand and provision during the evenings and at weekends.

Clinical and experimental dermatology·2021
Same author

What's new in atopic eczema? An analysis of systematic reviews published in 2018. Part 1: prevention and topical therapies.

Clinical and experimental dermatology·2020
Same author

What's new in atopic eczema? An analysis of systematic reviews published in 2018. Part 2: systemic therapies.

Clinical and experimental dermatology·2020

Related Experiment Video

Updated: Nov 11, 2025

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

815

Toxic epidermal necrolysis-like lupus.

E J Roberts1, V Melchionda1, G Saldanha2

  • 1Dermatology Department, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, UK.

Clinical and Experimental Dermatology
|March 24, 2021
PubMed
Summary
This summary is machine-generated.

Toxic epidermal necrosis (TEN)-like lupus is a rare condition mimicking drug reactions. Early diagnosis and rheumatologist intervention with immunosuppressants are crucial for managing this severe lupus flare.

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

460
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

333

Related Experiment Videos

Last Updated: Nov 11, 2025

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

815
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

460
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

333

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Toxic epidermal necrosis (TEN)-like lupus is a rare condition.
  • It presents during acute, severe flares of systemic lupus erythematosus (SLE).
  • It can be mistaken for drug-induced Stevens-Johnson syndrome/TEN.

Observation:

  • A case series of three patients with TEN-like lupus was analyzed.
  • Key differentiating features included slower epidermal loss and less mucosal/ocular involvement compared to drug-induced TEN.
  • Histological findings showed basal cell vacuolation, apoptosis, and full-thickness epidermal necrosis.

Findings:

  • TEN-like lupus is distinct from drug-induced TEN, characterized by specific clinical and histological features.
  • Patients often exhibit additional SLE manifestations and may have a positive lupus band test.
  • Accurate diagnosis is essential for appropriate patient management.

Implications:

  • Early recognition of TEN-like lupus is critical for effective treatment.
  • Prompt consultation with Rheumatologists is recommended.
  • High-dose combined immunosuppressant therapy is the suggested management approach.