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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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P53 long noncoding RNA regulatory network in cancer development.

Surendar Aravindhan1, Laith A Younus2, Methaq Hadi Lafta3

  • 1Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, chennai, India.

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|March 24, 2021
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Summary

The tumor suppressor protein p53 and long noncoding RNAs (lncRNAs) interact to regulate gene expression, impacting cell cycle and apoptosis in cancer. Understanding this crosstalk is crucial for cancer therapy development.

Keywords:
P53cancerlong noncoding RNAnoncoding RNAregulatory networktumor genetic

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The protein p53 functions as a transcription factor with significant tumor-suppressive activities, crucial for DNA damage recognition, repair, and apoptosis.
  • Alterations in p53 are common in human malignancies, and its pathway deregulation drives carcinogenesis and tumor progression.
  • The role of p53 in regulating long noncoding RNAs (lncRNAs) and their impact on cancer biology is increasingly recognized.

Purpose of the Study:

  • To review the intricate relationship between p53 pathways and lncRNAs in cancer.
  • To elucidate the mechanisms of crosstalk between lncRNAs and p53 in various cancer types.
  • To highlight the significance of lncRNA-p53 interactions in controlling cell cycle and apoptosis.

Main Methods:

  • Literature review of studies investigating p53 and lncRNA interactions in cancer.
  • Analysis of molecular mechanisms linking p53 transcriptional response to lncRNA regulation.
  • Examination of lncRNA roles in modulating p53 signaling networks.

Main Results:

  • p53 induces or suppresses lncRNAs, which in turn regulate cancer progression.
  • lncRNAs act as key regulators within the p53 signaling network, influencing global gene expression.
  • Aberrant lncRNA expression serves as a molecular-genomic signature in cancer biology.

Conclusions:

  • The crosstalk between lncRNAs and p53 is a critical determinant of cell cycle control and apoptosis in cancer.
  • Understanding these interactions is essential for developing novel cancer diagnostics and therapeutics.
  • Further research into lncRNA-p53 mechanisms can uncover new therapeutic targets for various cancers.