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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.7K
T Cell Types and Functions01:24

T Cell Types and Functions

1.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

128
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
128
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

165
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
165

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Updated: Nov 11, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

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[COVID-19 AND AUTOIMMUNE DISEASES].

Arad Dotan1, Yehuda Shoenfeld2,3

  • 1MD MPH studies, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Harefuah
|March 24, 2021
PubMed
Summary

The COVID-19 virus can trigger autoimmune responses by overstimulating the immune system and mimicking human proteins. This can lead to autoantibodies and autoimmune diseases in patients.

Area of Science:

  • Immunology
  • Virology
  • Autoimmunity

Background:

  • Immune system function is influenced by hereditary, environmental, and hormonal factors.
  • Viral infections, particularly COVID-19, are significant environmental factors impacting immune responses.
  • Deviations in these factors can predispose individuals to autoimmune diseases and lymphoma.

Purpose of the Study:

  • To highlight the autoimmune effects of the COVID-19 virus.
  • To explain the mechanisms by which SARS-CoV-2 induces autoimmunity.
  • To emphasize the clinical importance of recognizing these effects during the pandemic.

Main Methods:

  • Review of recent evidence and case reports on COVID-19 and autoimmunity.
  • Analysis of the mechanisms of viral-induced immune hyper-stimulation.

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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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  • Examination of molecular mimicry between SARS-CoV-2 and human proteins.

    • Main Results:

    • COVID-19 virus can cause immune system hyper-stimulation, leading to autoantibody formation.
    • Molecular mimicry between the virus and host tissues contributes to autoimmune reactions.
    • Severely ill COVID-19 patients frequently develop autoantibodies associated with common autoimmune diseases.
    • Published case reports link COVID-19 infection to the onset of autoimmune diseases.

    Conclusions:

    • COVID-19 has a significant potential to induce autoimmune phenomena.
    • Recognition of SARS-CoV-2-induced autoimmunity is crucial for patient management.
    • Understanding these effects is vital in addressing the ongoing pandemic's broader health implications.