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COVID-19-Associated Mold Infection in Critically Ill Patients, Chile

Ricardo Rabagliati, Nicolás Rodríguez, Carolina Núñez

    Emerging Infectious Diseases
    |March 24, 2021
    PubMed

    Insights

    Severe COVID-19 patients can develop invasive mold infections (CAIMI). In Chile, 11% of non-immunocompromised severe COVID-19 patients had CAIMI, with a 31.2% mortality rate.

    Area of Science:

    • Infectious Diseases
    • Critical Care Medicine
    • Pulmonology

    Background:

    • Severe coronavirus disease (COVID-19) is a global health crisis.
    • Invasive fungal infections are a known complication in critically ill patients.
    • The incidence and impact of COVID-19-associated invasive mold infection (CAIMI) in non-immunocompromised patients require further investigation.

    Purpose of the Study:

    • To determine the incidence of CAIMI in non-immunocompromised patients with severe COVID-19.
    • To report on the clinical characteristics and outcomes of patients with CAIMI.

    Main Methods:

    • Retrospective case series.
    • Inclusion of 146 non-immunocompromised patients with severe COVID-19 admitted to an academic hospital in Santiago, Chile.
    • Identification and analysis of patients diagnosed with CAIMI.

    Main Results:

    • Sixteen cases of CAIMI were identified among 146 patients, representing an 11% incidence rate.
    • The mortality rate among patients with CAIMI was 31.2%.
    • The study highlights a significant burden of CAIMI in this patient population.

    Conclusions:

    • CAIMI is a significant complication in non-immunocompromised patients with severe COVID-19.
    • Early recognition and management of CAIMI are crucial for improving patient outcomes.
    • Further research is warranted to understand the pathophysiology and optimize treatment strategies for CAIMI.
    Keywords:
    2019 novel coronavirus diseaseCOVID-19COVID-19–associated invasive mold infectionChileSARS-CoV-2coronaviruscoronavirus diseasefungirespiratory infectionssevere acute respiratory syndrome coronavirus 2viruseszoonoses

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