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Updated: Nov 11, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Is metformin effective for reducing weight in obese or overweight adolescents?
Kirsten Anderson1, Gary Kelsberg1, Sarah Safranek2
1Valley Family Medicine Residency, University of Washington at Valley, Renton, USA.
Abstract:
YES, TO SOME DEGREE-BUT IT IS OF UNCERTAIN CLINICAL SIGNIFICANCE. OVER A PERIOD OF 6 MONTHS, METFORMIN MODESTLY REDUCED WEIGHT (-2.1 KG) AND BODY FAT MASS (-1.9%), BUT NOT BODY MASS INDEX (BMI) OR LEAN BODY MASS, IN ADOLESCENTS WHO WERE OVERWEIGHT OR OBESE. THIS IS COMPARABLE TO LIFESTYLE INTERVENTIONS (DIET AND EXERCISE) SUPPORTED WITH > 26 HOURS OF COUNSELING, WHICH MODESTLY IMPROVED BMI BUT NOT WEIGHT. (STRENGTH OF RECOMMENDATION [SOR]: A, BASED ON A LARGE META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS [RCTS] OF VARIABLE QUALITY).
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