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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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[Problems of differential diagnosis in children with acute leukemia]

K Hählen1, F A Nabben, A J Veerman

  • 1Afd. Kindergeneeskunde, Sophia Kinderziekenhuis, Erasmus Universiteit, Rotterdam.

Tijdschrift Voor Kindergeneeskunde
|April 1, 1988
PubMed

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...