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Megaprepuce: a systematic review of a rare condition with a controversial surgical management
Mohamed Shalaby1, Salvatore Cascio2
1Department of Paediatric Surgery, Bristol Royal Hospital for Children, Bristol, BS2 8BJ, UK. mshalaby@doctors.org.uk.
Abstract:
Megaprepuce (MP) is a rare and challenging condition characterised by an excessive inner prepuce, paucity of penile skin and an extremely narrow phimotic ring. The aetiological factors leading to its development are poorly understood. A variety of surgical techniques have been described in the last 26 years mostly with small number of patients and short follow-up. It is also highly likely that some series have in the past included different variants of inconspicuous penis combining concealed penis, MP and webbed penis. This article is a systematic review of the literature on Megaprepuce; in particular the embryology, history, aetiology, and the surgical techniques available for the correction of this unique penile anomaly will be presented and discussed in this study.
Insights
Megaprepuce (MP), a rare penile anomaly, involves excessive inner prepuce and a narrow phimotic ring. This review discusses its embryology, etiology, and surgical correction techniques.
Area of Science:
- Urology
- Pediatric Surgery
- Medical Genetics
Background:
- Megaprepuce (MP) is a rare congenital penile anomaly characterized by an excessively redundant inner prepuce, limited penile skin, and a narrow phimotic ring.
- The precise etiological factors underlying megaprepuce development remain poorly understood.
- Existing literature often includes varied presentations of inconspicuous penis, potentially confounding the understanding of MP.
Purpose of the Study:
- To conduct a systematic literature review on megaprepuce.
- To present and discuss the embryology, history, and etiology of this unique penile anomaly.
- To provide a comprehensive overview of surgical techniques for megaprepuce correction.
Main Methods:
- Systematic review of existing medical literature.
- Analysis of studies published over the last 26 years.
- Synthesis of information regarding embryology, etiology, and surgical interventions.
Main Results:
- The etiology of megaprepuce is not well-established.
- Numerous surgical techniques have been reported, often with limited patient numbers and short follow-up periods.
- Potential overlap with other penile anomalies like concealed and webbed penis complicates historical data analysis.
Conclusions:
- Megaprepuce represents a distinct penile anomaly requiring specific diagnostic and therapeutic approaches.
- Further research is needed to elucidate the etiology and optimize surgical outcomes.
- Standardization of definitions and reporting is crucial for future studies on megaprepuce.
