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Pneumococci resistant to erythromycin.

J M Dixon, A E Lipinski

    Canadian Medical Association Journal
    |November 4, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Erythromycin resistance in pneumococci emerged in Alberta after October 1973, affecting 0.71% of isolates. These resistant strains, including novel types, remained susceptible to penicillin.

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    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Streptococcus pneumoniae (pneumococci) are a leading cause of bacterial infections.
    • Erythromycin is a crucial antibiotic for treating pneumococcal infections.
    • Monitoring antibiotic resistance is vital for public health.

    Purpose of the Study:

    • To determine the prevalence and characteristics of erythromycin-resistant pneumococci.
    • To track the emergence and spread of erythromycin resistance in pneumococci.
    • To assess the susceptibility of resistant strains to other antibiotics.

    Main Methods:

    • Isolation and susceptibility testing of pneumococci from clinical specimens.
    • Monitoring erythromycin resistance from 1969 to 1977.

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  • Characterization of resistant strains, including capsular typing and MIC determination.
  • Testing resistance to lincomycin, clindamycin, and penicillin.

    • Main Results:

    • Erythromycin resistance emerged in pneumococci isolates after October 1973.
    • 0.71% (64/8995) of isolates were resistant between October 1973 and December 1977.
    • Resistant strains were found in multiple communities and represented nine capsular types.
    • Some strains showed high-level resistance (MIC 2000 µg/mL) to erythromycin, lincomycin, and clindamycin.
    • All resistant strains remained susceptible to penicillin.

    Conclusions:

    • Erythromycin resistance in pneumococci emerged in Alberta during the study period.
    • The emergence of resistance involved diverse capsular types, some previously unreported.
    • High-level resistance to erythromycin, lincomycin, and clindamycin was observed in specific strains.
    • Penicillin remains an effective treatment option for erythromycin-resistant pneumococcal infections.