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Nrf2 a molecular therapeutic target for Astaxanthin

Zeynab Kohandel1, Tahereh Farkhondeh2, Michael Aschner3

  • 1Department of Biology, Faculty of Sciences, University of Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 25, 2021
PubMed

Insights

Astaxanthin (ATX), a potent antioxidant, demonstrates significant anti-cancer, anti-aging, and protective effects across multiple organs. Its benefits are largely mediated by the Nrf2 pathway, highlighting its therapeutic potential.

Area of Science:

  • Nutritional Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Astaxanthin (ATX) is a natural carotenoid pigment found in various marine organisms.
  • ATX is recognized for its potent antioxidant capabilities.
  • Emerging research indicates ATX possesses anti-inflammatory, anti-apoptotic, and anti-proliferative activities.

Purpose of the Study:

  • To review the multifaceted health benefits of Astaxanthin.
  • To elucidate the role of Nuclear factor erythroid 2-related factor 2 (Nrf2) in mediating ATX's effects.
  • To consolidate evidence for ATX's protective roles in various physiological systems.

Main Methods:

  • Literature review of existing scientific studies on Astaxanthin.
  • Analysis of research focusing on the Nrf2 signaling pathway.
  • Synthesis of data regarding ATX's impact on cellular and organ protection.

Main Results:

  • Astaxanthin exhibits significant antioxidant and anti-inflammatory properties.
  • Nrf2 activation is a key mechanism underlying ATX's therapeutic effects.
  • ATX demonstrates protective benefits for the brain, lungs, skin, heart, liver, and muscles, and shows potential in anti-diabetic and anti-aging applications.

Conclusions:

  • Astaxanthin is a promising nutraceutical with broad-spectrum health benefits.
  • The Nrf2 pathway is crucial for mediating the protective effects of Astaxanthin.
  • Further research into ATX and Nrf2 interactions could lead to novel therapeutic strategies.
Keywords:
AstaxanthinInflammationNrf2Oxidative stress

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