Related Experiment Video

Updated: Nov 11, 2025

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
11:11

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells

Published on: April 25, 2018

8.4K

FENDRR: A pivotal, cancer-related, long non-coding RNA

Qingyuan Zheng1, Qiyao Zhang1, Xiao Yu1

  • 1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 25, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate biological functions and are implicated in cancer. Fetal-lethal non-coding developmental regulatory RNA (FENDRR) shows potential as a cancer biomarker for diagnosis, prognosis, and treatment.

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Long non-coding RNAs (lncRNAs) are critical regulators of biological processes.
  • Dysregulation of lncRNAs is linked to various diseases, particularly cancer.
  • FENDRR (FOXF1-AS1) is an emerging lncRNA implicated in cancer pathogenesis.

Purpose of the Study:

  • To review the current understanding of FENDRR's role in cancer.
  • To explore FENDRR's mechanistic functions in cancer progression.
  • To discuss the clinical significance of FENDRR as a cancer biomarker.

Main Methods:

  • Literature review of studies on FENDRR and cancer.
  • Analysis of FENDRR expression patterns in various cancers.
  • Examination of FENDRR's involvement in cancer development and progression.

Main Results:

  • FENDRR is abnormally expressed across diverse cancer types.
  • FENDRR expression correlates with distinct clinical characteristics.
  • FENDRR demonstrates potential as a biomarker for cancer diagnosis, prognosis, and treatment efficacy.

Conclusions:

  • FENDRR is a significant lncRNA in cancer biology.
  • FENDRR plays a crucial role in cancer progression.
  • FENDRR holds promise as a valuable clinical biomarker for cancer management.
Keywords:
BiomarkerCancerFENDRRLncRNATherapeutic target

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

835
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

576

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.7K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.7K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.5K
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.4K