Related Experiment Video

Updated: Nov 11, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

5.8K

Modulation of untranslated region alternative polyadenylation in glioma tumorigenesis

Yu-Long Lan1, Jianmin Zhang1

  • 1Department of Neurosurgery, Second Affiliated Hospital, School of medicine, Zhejiang University, Hangzhou, 310000, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 25, 2021
PubMed

Insights

Alternative polyadenylation (APA) dysregulation is crucial in glioma development. Targeting APA regulators offers a promising therapeutic strategy for improving glioma patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • RNA modifications regulate gene expression and are critical in cancer biology.
  • Dysregulation of RNA modifications, particularly alternative polyadenylation (APA), is implicated in glioma pathogenesis.
  • APA may enable genes to evade microRNA-mediated cancer inhibition, with 3'-UTR shortening as a potential cancer progression marker.

Purpose of the Study:

  • To review the significant roles of untranslated region-alternative polyadenylation (UTR-APA) in glioma.
  • To explore the mechanisms of UTR-APA in glioma progression.
  • To discuss potential therapeutic strategies targeting UTR-APA for improved glioma prognosis.

Main Methods:

  • Literature review focusing on UTR-APA mechanisms and their role in glioma.
  • Analysis of current research on APA regulators as therapeutic targets.
  • Synthesis of information on APA's impact on glioma pathogenesis and progression.

Main Results:

  • APA, especially 3'-UTR shortening, is a key mechanism in glioma development.
  • APA regulators represent potential targets for less targeted therapeutic strategies in glioma.
  • Understanding UTR-APA mechanisms is crucial for developing effective glioma treatments.

Conclusions:

  • UTR-APA plays a vital role in glioma progression and presents a novel therapeutic avenue.
  • Targeting APA regulators may offer superior therapeutic benefits compared to single-gene or pathway-specific treatments for glioma.
  • Further research into UTR-APA mechanisms is essential for improving glioma patient prognosis.
Keywords:
Alternative polyadenylationGliomaModulation

More Related Videos

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

9.7K
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.2K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.9K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
10.0K
Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.6K
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.4K
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
58.6K