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Updated: Nov 11, 2025

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His bundle pacing therapy for patients with chronic heart failure: A protocol for meta-analysis based on prospective

Yongzheng Zhang1, Mingwang Ding, Zhihong Pu

  • 1Department of CCU, Gansu Provincial Third Hospital, Lanzhou, China.

Medicine
|March 25, 2021
PubMed

Insights

This meta-analysis will evaluate the clinical effectiveness of His bundle pacing (HBP) for patients with chronic heart failure (CHF). It aims to clarify the benefits of HBP therapy in managing heart failure symptoms and improving patient outcomes.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Existing studies on His bundle pacing (HBP) for chronic heart failure (CHF) yield inconclusive results.
  • Clinical benefit of HBP in CHF patients requires further clarification for widespread adoption.
  • A systematic review and meta-analysis is needed to consolidate evidence.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis evaluating the efficacy of His bundle pacing (HBP) therapy.
  • To assess the impact of HBP on chronic heart failure (CHF) patients.
  • To provide a definitive conclusion on HBP's role in CHF management.

Main Methods:

  • Extensive literature search across major databases (PubMed, EMBASE, Cochrane, Web of Science, Chinese databases) up to November 2020.
  • Utilizing STATA 13.0 for robust data synthesis and statistical meta-analysis.
  • Inclusion of studies reporting on HBP therapy for chronic heart failure.

Main Results:

  • Analysis of key outcome measures including QRS duration and left ventricular ejection fraction.
  • Evaluation of functional status using New York Heart Association (NYHA) classification.
  • Assessment of cardiac structure and function, including ventricular diameters and regurgitation severity, alongside BNP levels.

Conclusions:

  • This meta-analysis will synthesize current evidence on His bundle pacing for chronic heart failure.
  • The findings will aim to resolve uncertainties regarding the clinical utility of HBP in CHF.
  • The study will provide evidence-based recommendations for clinicians considering HBP therapy.
Abstract

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