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SMOFlipid causing spuriously high serum total bilirubin in an extremely premature neonate

Jia Ming Low1, Tze Ping Loh2, Zubair Amin1

  • 1Department of Neonatology, Khoo Teck Puat-National University Children Medical Institute, Singapore.

Pathology
|March 25, 2021
PubMed
Abstract

No abstract available in PubMed .

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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