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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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How old is too old for a transplant?

Daniel Weisdorf1

  • 1Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, MMC 480, Minneapolis, MN, 55455, USA.

Best Practice & Research. Clinical Haematology
|March 25, 2021
PubMed
Summary

Allogeneic transplantation offers a cure for acute myeloid leukemia (AML). Older AML patients can benefit from this treatment, but decisions must balance health status and patient wishes, not just age.

Keywords:
AgeAllogeneic transplantFrailtyNon-relapse mortality

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Area of Science:

  • Hematology
  • Oncology
  • Transplant Medicine

Background:

  • Allogeneic transplantation is a curative option for acute myeloid leukemia (AML).
  • Older adults (≥60s) are diagnosed with AML but often excluded from transplant due to age, comorbidities, and disease risk.
  • Decision-making for older AML patients involves complex factors beyond chronological age.

Purpose of the Study:

  • To evaluate the role and decision-making process for allogeneic transplantation in older acute myeloid leukemia patients.
  • To emphasize a comprehensive assessment beyond chronological age for transplant eligibility.

Main Methods:

  • Review of recent analyses and clinical considerations for older AML patients.
  • Assessment of factors influencing transplant decisions in the elderly AML population.

Main Results:

  • Recent data suggest promising outcomes for older AML patients undergoing allogeneic transplantation.
  • Factors like performance status, frailty, and donor availability are critical in decision-making.
  • Patient's wishes, life goals, and risk understanding are paramount.

Conclusions:

  • Chronological age alone should not restrict older AML patients from potentially curative allogeneic transplantation.
  • A balanced assessment considering individual patient factors is essential for optimizing transplant access and outcomes.
  • Individualized care plans are crucial for elderly AML patients considering stem cell transplant.