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Oncometabolites in Cancer: Current Understanding and Challenges
1Neuro-Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Cancer Research
|March 25, 2021
Summary
Oncometabolites, altered in cancers like glioma, disrupt the Krebs cycle and impact enzymes. Understanding these oncometabolites offers new therapeutic strategies for cancer treatment.
Area of Science:
- Biochemistry
- Oncology
- Metabolomics
Background:
- Oncometabolites are key indicators in various human cancers, including glioma, leukemia, neuroendocrine tumors, and renal cancer.
- Their accumulation stems from disruptions in the Krebs cycle, affecting critical enzymes like α-ketoglutarate-dependent dioxygenases.
Purpose of the Study:
- To review the current knowledge on oncometabolites in cancer.
- To discuss controversies and challenges in understanding oncometabolite-driven cancers.
- To highlight the potential of oncometabolites for novel cancer therapies.
Main Methods:
- Literature review and synthesis of current research on oncometabolites.
- Analysis of the role of oncometabolites in cancer hallmarks, metabolism, and therapeutic resistance.
Main Results:
- Oncometabolites are significantly linked to oncogenesis, metabolic reprogramming, and treatment resistance in diverse cancers.
- Disrupted Krebs cycle function leads to aberrant oncometabolite accumulation.
Conclusions:
- Oncometabolites represent crucial targets for cancer research and therapy.
- Further insights into oncometabolite-cancer relationships can unlock innovative treatment strategies.
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