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Related Concept Videos

Ischemic Heart Disease: Overview01:17

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Related Experiment Video

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Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
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[Ischemic Stroke].

Ayako Kuriki1, Yuki Kamiya

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|March 25, 2021
PubMed
Summary
This summary is machine-generated.

Early CT and MRI signs, including hyperdense artery signs, are crucial for diagnosing acute cerebral embolism. Advanced imaging like MRA, SVS, and FVH helps pinpoint occluded vessels for effective endovascular therapy.

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Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • A patient with chronic atrial fibrillation presented with sudden right hemiparalysis.
  • Initial assessment revealed early ischemic changes on Head CT (ASPECTS 6) and a hyperdense internal carotid artery (ICA) sign.

Purpose of the Study:

  • To evaluate the utility of early CT and advanced MRI techniques in diagnosing acute cerebral embolism.
  • To correlate imaging findings with treatment outcomes.

Main Methods:

  • Head CT with ASPECTS scoring.
  • MRI including Diffusion-Weighted Imaging (DWI)-ASPECTS, Magnetic Resonance Angiography (MRA), T2*-weighted imaging (T2*WI) for susceptibility vessel sign (SVS), and FLAIR for vessel hyperintensity (FVH).
  • Diagnosis of acute cerebral embolism with clinical-DWI mismatch.

Main Results:

  • CT showed early ischemic changes and a hyperdense left ICA.
  • MRI DWI-ASPECTS confirmed early ischemic changes.
  • MRA demonstrated occlusion of the left ICA, anterior cerebral artery, and middle cerebral artery.
  • SVS and FVH localized the occlusion to the left ICA.

Conclusions:

  • Hyperdense ICA/MCA signs on early CT are valuable for identifying occluded vessels in acute ischemic stroke.
  • MRI-DWI is more sensitive for detecting early ischemic changes.
  • Combined evaluation of MRA, SVS, and FVH aids in precise localization of the occluded vessel, guiding endovascular therapy.