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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer Survival Analysis01:21

Cancer Survival Analysis

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Nov 11, 2025

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Clinical cancer genomic profiling.

Debyani Chakravarty1,2, David B Solit3,4

  • 1Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature Reviews. Genetics
|March 25, 2021
PubMed
Summary
This summary is machine-generated.

Genomic profiling in cancer care is advancing, improving tumor classification and therapy selection. Future strategies include integrating tumor and germline data for enhanced clinical utility.

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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Last Updated: Nov 11, 2025

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Area of Science:

  • Oncology
  • Genomics
  • Bioinformatics

Background:

  • Technological advancements and reduced sequencing costs facilitate genomic profiling in routine cancer care.
  • Tumor genomic profiling aids in refining cancer subtypes, predicting response to systemic therapies, and identifying heritable cancer risks.

Purpose of the Study:

  • To discuss strategies for enhancing the clinical utility of tumor genomic profiling.
  • To explore the integration of tumor and germline analyses, allelic context characterization, and mutational signature identification.
  • To review the potential of comprehensive sequencing and cell-free DNA profiling for minimally invasive monitoring.

Main Methods:

  • Review of ongoing research and clinical efforts in tumor genomic profiling.
  • Discussion of integrated tumor and germline analysis approaches.
  • Exploration of advanced sequencing technologies (whole-genome, whole-transcriptome) and cell-free DNA (cfDNA) profiling.

Main Results:

  • Genomic profiling refines cancer classification and identifies patients likely to benefit from specific therapies.
  • Integration of tumor and germline data, allelic context, and mutational signatures can improve therapeutic strategies.
  • Emerging technologies like whole-genome sequencing and cfDNA analysis offer potential for non-invasive, serial monitoring.

Conclusions:

  • Enhanced tumor genomic profiling, through integrated analyses and advanced technologies, promises to significantly improve cancer diagnosis, treatment selection, and patient monitoring.
  • Minimally invasive approaches like cfDNA profiling hold potential for serial monitoring of treatment response and disease recurrence.