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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Two Fatty Liver Conditions Masquerading as Autoimmune Hepatitis
Jonathan David Hendrie1, Mary Crouse Blumer1, Hubert Henry Fenton2
1Prisma Health-Upstate, University of South Carolina School of Medicine-Greenville, Department of Medicine, 701 Grove Rd., Greenville, SC 29605, USA.
This case report details the earliest presentation of acute fatty liver of pregnancy (AFLP) at 15 weeks gestation, complicated by high-titer antinuclear antibodies. The patient experienced intrauterine fetal demise, sepsis, and multisystem organ failure, ultimately expiring without transplant.
Area of Science:
- Obstetrics and Gynecology
- Hepatology
- Immunology
Background:
- Acute fatty liver of pregnancy (AFLP) is a rare, severe condition typically seen in the third trimester.
- Early second-trimester AFLP is exceptionally rare, with only six prior English literature cases.
- High-titer antinuclear antibodies (ANA) can mimic autoimmune hepatitis, complicating AFLP diagnosis.
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