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Populating preterm infants with probiotics

Matthew J Dalby1, Lindsay J Hall1,2,3

  • 1Gut Microbes & Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.

Cell Reports. Medicine
|March 25, 2021
PubMed

Insights

Probiotic supplementation in premature infants can alter the gut microbiota shortly after birth, according to a randomized trial. This intervention may influence early infant gut microbiome development.

Area of Science:

  • Neonatal research
  • Microbiome science
  • Clinical nutrition

Background:

  • The gut microbiota plays a crucial role in infant health and development.
  • Premature infants often exhibit altered gut microbiome composition.
  • Early life interventions are being explored to optimize infant gut health.

Purpose of the Study:

  • To investigate the effect of probiotic supplementation on the gut microbiota of premature infants.
  • To determine if early probiotic intervention can modulate the infant gut microbiome composition.

Main Methods:

  • A randomized, placebo-controlled trial design was employed.
  • Probiotic supplementation was administered to premature infants.
  • Gut microbiota composition was analyzed post-supplementation.

Main Results:

  • Probiotic supplementation significantly modulated the infant gut microbiota composition.
  • Specific microbial changes were observed in infants receiving probiotics compared to placebo.

Conclusions:

  • Probiotic supplementation is an effective strategy for modulating the gut microbiota in premature infants.
  • Early intervention with probiotics may influence the developing infant gut microbiome.

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