Sex and Gender Differences in Clinical Pharmacology: Implications for Transgender Medicine

Lauren R Cirrincione1, Kai J Huang2

  • 1Department of Pharmacy, University of Washington, Seattle, Washington, USA.

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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